Vol. 1, Issue 1, Part F (2014)

Background: Numerous factors contribute to the widespread prevalence of chronic kidney disease (CKD). Hyperhomocysteinemia has been linked to increased cardiovascular morbidity and mortality, and it has been reported that chronic renal disease is a leading cause of this condition.

Material and Methods: This was a prospective, single-center study that was carried out at the Department of General Medicine, Annali Medical Callege and Hospital, Chennai, Tamil Nadu. It was done by the departments of general medicine and nephrology. The study took place over eight months, from February 2013 to February 2014. 40 patients with chronic kidney disease who were admitted to Annali Medical Callege and Hospital, Chennai, Tamil Nadu and hospital met the standards for inclusion and exclusion.

Observations and Results: Thirty-seven of the 40 cases were men, while 13 were women. There were 34 patients between the ages of 41 and 60. There were 36 patients at Stage 5, 11 at Stage 4, and 3 at Stage 3 of chronic kidney disease. Seventy-eight percent of CKD patients were found to have hyperhomocysteinemia. Hyperhomocysteinemia was mild in 94.87% of the sample. Patients with end-stage renal illness were more likely to have elevated homocysteine levels.

Conclusion: Patients on dialysis and those who are not did not differ significantly in their levels of hyperhomocysteinemia. Patients with CKD frequently suffer from hyperhomocysteinemia.