Vol. 1, Issue 1, Part F (2014)

Introduction: Inflammation plays a pivotal role in the pathogenesis of Type 2 Diabetes Mellitus (T2DM). High-Sensitivity C-Reactive Protein (hs-CRP) is a sensitive marker of inflammation and may be associated with impaired glycemic control in T2DM. The aim of the study was to evaluate the relationship between hs-CRP levels and glycemic indices in T2DM patients and to explore the impact of demographic factors, lifestyle choices, and diabetes medication on hs-CRP levels.

Material and Methods: This cross-sectional study included 100 subjects from the Department of Biochemistry, Mamata Medical College, Khammam, comprising 50 T2DM patients and 50 healthy controls. hs-CRP levels were measured along with fasting blood glucose and HbA1c. Subgroup analyses were conducted based on BMI, diabetes duration, medication type, and lifestyle factors.

Results: The T2DM group exhibited significantly higher hs-CRP levels compared to controls (p< 0.001). There was a positive correlation between hs-CRP levels and both fasting glucose (r = 0.45, p< 0.01) and HbA1c (r = 0.50, p< 0.001). Patients with higher BMI showed elevated hs-CRP levels (p< 0.01). Metformin use was associated with a significant reduction in hs-CRP levels (p< 0.05). Regular physical activity was inversely correlated with hs-CRP levels (p< 0.05).

Conclusion: Elevated hs-CRP levels in T2DM patients are associated with poor glycemic control. Obesity, physical inactivity, and absence of metformin therapy contribute to higher hs-CRP levels. The findings highlight the importance of considering inflammatory markers in the management of T2DM and suggest the potential benefit of anti-inflammatory strategies.