- Multidisciplinary Journal
- Printed Journal
- Indexed Journal
- Refereed Journal
- Peer Reviewed Journal
ISSN Print: 2394-7500, ISSN Online: 2394-5869, CODEN: IJARPF
IMPACT FACTOR (RJIF): 8.4
Important Information
- Helpline for Authors
- India: +91-9711224068
- Toll Free (India): 18001234070
- Working hours: 10:00 AM-06:00 PM
Issue Bar
Side Bar
Identifier
Vol. 10, Issue 2, Part A (2024)
Maternal and fetal outcome in intrahepatic cholestasis of pregnancy at tertiary care institute: A prospective study
Maternal and fetal outcome in intrahepatic cholestasis of pregnancy at tertiary care institute: A prospective study
Author(s)
Abstract
Introduction:Intrahepatic cholestasis of pregnancy (IHCP) is characterized by pruritus of the hand and sole with abnormal liver function test and bile acid metabolism. IHCP occurs in the second and third trimesters of pregnancy and usually resolves after delivery. The overall prevalence is about 1.2 to 1.5%. This study was conducted to assess the fetomaternal outcome according to maternal serum bile acids levels and its correlation with liver function tests in patients with IHCP.
Introduction:Intrahepatic cholestasis of pregnancy (IHCP) is characterized by pruritus of the hand and sole with abnormal liver function test and bile acid metabolism. IHCP occurs in the second and third trimesters of pregnancy and usually resolves after delivery. The overall prevalence is about 1.2 to 1.5%. This study was conducted to assess the fetomaternal outcome according to maternal serum bile acids levels and its correlation with liver function tests in patients with IHCP.
Methods: This hospital based analytical observational case control study enrolled 44 subjects with IHCP and 44 normal healthy pregnant controls. The subjects were assessed for demographic parameters, obstetric history, liver function tests including Bile acids. Outcome was measured as various parameters related to delivery and maternal and fetal complications.
Results: Study groups were matched for age (0.52). Frequency of primipara was higher in IHCP (p=0.01). Serum bilirubin (p=0.002), liver enzymes (p<0.0001 for all) and Bile acids (p=0.001) were significantly elevated in IHCP subjects compared to controls. Further, frequency of preterm birth was higher in IHCP (p=0.013). Fetal complications (p=0.01) and birth weight (p=0.03) were higher in IHCP subjects.
Conclusions: IHCP is associated with higher risk of complications in infants and to lesser extent in mothers.
Pages: 09-12 | 183 Views 92 Downloads
How to cite this article:
Dr. Zohra Younus, Dr. Mufeed Ahmad Bhat, Dr. Insha Yousuf. Maternal and fetal outcome in intrahepatic cholestasis of pregnancy at tertiary care institute: A prospective study. Int J Appl Res 2024;10(2):09-12.
Important Information
- Helpline for Authors
- India: +91-9711224068
- Toll Free (India): 18001234070
- Working hours: 10:00 AM-06:00 PM
Issue Bar
Side Bar
Identifier
Research Journals